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To prevent livers clearance and improve transfection efficiency, antibody-based (i.e., T cell membrane markers, CD3, CD4, CD8, CD5, etc.) membrane modifications can guide LNP retention in specific extrahepatic tissues 46,47,48,49

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5-Amino-1MQ can be conceptually paired with NAD+ precursors such as NMN or NR: the precursor supplies additional substrate, while 5-Amino-1MQ protects the recycling of nicotinamide that is already present